Vast diversity of human brain cell types revealed in trove of new datasets
The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.
Charting the structure and function of the brain’s many circuits may unravel autism’s mysteries.
The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.
Alterations in inhibitory circuits and difficulties in social recognition characterize mice missing one copy of DYRK1A, a gene linked to autism.
After 10 years of work, Neurona may have the data to quiet its skeptics. But its ongoing clinical trial will be the ultimate test.
The mutations disrupt protein translation as well as the cell’s skeleton, according to a new study.
The approach, which combines CRISPR with single-cell analyses of organoids, suggests that intermediate progenitor cells are especially vulnerable to mutations associated with autism.
Increasing or reducing the levels of the UBE3A gene, which is associated with autism and autism-related syndromes, results in altered patterns of synaptic pruning — a process that snips away brain cell connections.
A thin “micro-tether” and rotating connector facilitate uninterrupted, hours-long neural population recordings as the animals freely explore their environment.
A genome-wide association study lays a foundation for deeper investigation of these variants in neurodevelopmental conditions.
The underlying regional neurobiology of the conditions may differ from person to person.
An imbalance in the number of excitatory neurons in early brain development may account for the difference.