Tag: valproic acid

April 2017
20170412-Ploypharmacyhand1900
Features / Deep Dive

Autism’s drug problem

by  /  19 April 2017

Many people on the spectrum take multiple medications — which can lead to serious side effects and may not even be effective.

3 Comments
July 2016
Getty Images / fotografixx
News

Epilepsy in family members raises risk of autism

by  /  21 July 2016

A study of more than 85,000 people with epilepsy and their immediate relatives suggests that epilepsy and autism share biological roots.

1 Comment
October 2015
Light switch: Turning off a circuit that connects distant brain regions improves social behaviors in a mouse model of autism.
News

Three autism mouse models marked by defects in same circuit

by  /  22 October 2015

Problems with social interactions stem from faulty wiring of a single circuit spanning distant brain regions, results from three mouse models of autism suggest.

0 Comments
Sniff test: Rats treated with a drug that blocks the hormone vasopressin spend more time sniffing other rats, a sign of improved social interactions.©iStock.com/nanka-stalker
News

Vasopressin blocker improves social deficits in rat autism model

by  /  19 October 2015

A drug that blocks the function of the hormone vasopressin improves social interactions and memory in rats that model autism.

0 Comments
July 2015
20150729toolboxmarmosets
News / Toolbox

Marmosets that miss social cues may mimic autism

by  /  29 July 2015

Marmosets exposed to an epilepsy drug in the womb do not recognize reciprocity — the social give-and-take that is a challenge for some people with autism — suggests a new study. The findings add to mounting evidence that these tiny monkeys offer clues about autism.

0 Comments
November 2014
20141120sfnhyperemotionalrats
News

Enriched environment staves off autism-like behavior in rats

by  /  20 November 2014

Rats exposed in utero to the epilepsy drug valproic acid, a risk factor for autism, do not develop autism-like behaviors if they are reared in a stimulating environment. Researchers presented the unpublished findings yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

0 Comments
20141116sfnnewshdactadpoles
News

Tadpole model links epilepsy drug’s effects to chromatin

by  /  16 November 2014

Valproic acid, an epilepsy drug that increases the risk of autism, may alter neural circuits by opening up chromatin, a tightly packaged form of DNA in the nucleus. Researchers presented the unpublished data today at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

0 Comments
February 2014
20140214inbriefmousegut
News

Cognition and behavior: Epilepsy drug alters rodent gut

by  /  14 February 2014

In utero exposure to the epilepsy drug valproic acid, which ups the risk of autism, may alter the composition of gut bacteria in rodents, according a study published 11 December in Brain Behavior and Immunity.

2 Comments
Opinion / Cross Talk

How to evaluate the ‘intense world’ paradigm?

by  /  11 February 2014

What evidence supports the idea that autism stems from overactive brain responses to sensory input? Researchers weigh in on this controversial theory.

11 Comments
January 2014
20140121viewpointfrithintense
Opinion / Viewpoint

Intense world theory raises intense worries

by ,  /  21 January 2014

The ‘intense world theory’ of autism, which has attracted much interest from the popular press, has received very little academic scrutiny. Uta Frith and Anna Remington ask: Is it as positive as it purports to be, and what does it mean for autism?

32 Comments
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