Tag: stem cells

April 2017
Multicolored mind: Fluorescent markers pinpoint cells inside a 'mini-brain' grown from human stem cells.M. Renner  et al. / The EMBO Journal
News / Toolbox

Lab-grown ‘mini-brains’ mimic brain development

by  /  28 April 2017

A new method for examining blobs of neurons known as ‘mini-brains’ reveals structures like those in the human brain.

0 Comments
March 2017
20170321-Muotri-1120crop2
Opinion / Viewpoint

With tweaks, brains in a dish may yield clear clues to autism

by  /  21 March 2017

‘Mini-brains’ created in a dish may reveal autism’s roots and point to treatments, but they do not yet mirror some critical features of a human brain.

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January 2017
Tour guide: A protein associated with autism (red) escorts RNA molecules across developing brain cells.
News

In immature brain cells, RNAs hitch ride with fragile X protein

by  /  18 January 2017

A clue to the origins of autism may exist among the molecules that transport RNA in the developing brain.

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Tissue tiers:  Intestinal organoids have layered folds (left) like those in the human gut, and working neurons (right, green).
News / Toolbox

Neurons talk to muscle cells in tiny test-tube intestine

by  /  6 January 2017

A new method allows researchers to transform stem cells into miniature intestines with a working nervous system.

0 Comments
November 2016
Short circuit: Stem cells derived from people with Angelman syndrome do not develop mature electrical firing patterns.
News

Faulty electrical activity keeps Angelman syndrome cells apart

by  /  16 November 2016

A new stem cell model of Angelman syndrome delivers evidence for three molecular mechanisms underlying the condition — and one potential treatment.

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Lab spheres: Organoids contain different types of cells arranged in layers similar to those found in the human brain.
News

‘Mini-brains’ may mimic only early brain development

by  /  15 November 2016

Gene expression in so-called ‘organoids’ resembles the pattern seen in the first few weeks of a developing brain.

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Signaling spheres: Neurons derived from skin cells communicate with each other in brain-like spheres.
News

Merging ‘mini-brains’ recapitulates brain’s electrical balance

by  /  15 November 2016

Fusing two spheres of neurons that either ramp up or tamp down brain activity yields neural networks like those in the developing brain.

0 Comments
Brain boost: An injection of stem cells can improve cognition in rats. 
© The Sanger Institute. Wellcome Images
News

Stem cell transplant makes rats more social

by  /  14 November 2016

Injecting stem cells into young rats makes them more social and flexible when learning tasks than before the treatment.

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October 2016
Structural issues: Neurons carrying mutations in Rett syndrome genes may have defects in microtubules (red), which form the cell skeleton. Robert S. McNeil / Science Source
News

Drug duo may reverse effects of Rett mutations in cells

by  /  21 October 2016

A pair of existing drugs normalizes the appearance and activity of neurons derived from the skin of individuals with Rett syndrome.

3 Comments
Mighty mimics:  Laboratory-grown microglia, the brain’s immune cells, could offer clues to Rett syndrome.Rudolph Jaenisch
News / Toolbox

Chemical cocktail creates microglia on demand

by  /  14 October 2016

A new method transforms lab-made stem cells into microglia, the brain’s immune cells.

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