Tag: SHANK1

June 2016
Features / Deep Dive

The treasures of monkey island

by  /  22 June 2016

On Cayo Santiago island, scientists track the alliances and power struggles of a colony of feral monkeys — collecting data to generate new insights into the social challenges that people with autism face.

3 Comments
January 2016
News

Neighboring mutations in gene may spawn separate conditions

by  /  25 January 2016

Two seemingly similar mutations in the SHANK3 gene have divergent effects on the brain and behavior.

1 Comment
July 2015
Opinion / Viewpoint

Rodent learning sheds light on missed social cues in autism

by  /  28 July 2015

Many people with autism have trouble interpreting and responding to social cues. Studying how rats learn from each other can provide insights into the human social brain, says Amiel Rosenkranz.

0 Comments
November 2014
News

Family of autism-linked proteins helps neurons communicate

by  /  16 November 2014

The SHANK family of proteins, some of which are strong autism candidates, work together to facilitate brain signaling, according to unpublished results presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

0 Comments
September 2014
News

SHANK3 mutations turn up in high proportion of autism cases

by  /  18 September 2014

About 2 percent of people who have both autism and intellectual disability carry harmful mutations in SHANK3, a protein that helps organize the connections between neurons, according to a study published 4 September in PLoS Genetics.

1 Comment
December 2013
News

Drug fixes cellular defects in autism-related disorder

by  /  2 December 2013

A new stem-cell model of Phelan-McDermid syndrome points to a possible treatment for the rare autism-related disorder, according to a study published in Nature.

3 Comments
November 2013
Opinion

Where will the focus on SHANK genes lead?

by  /  11 November 2013

Geneticists react to discoveries and identify next steps for one of autism’s most promising candidate genes.

2 Comments
Opinion / Viewpoint

SHANK mutations converge at neuronal junctions in autism

by ,  /  5 November 2013

SHANK3, one of the strongest candidate genes for autism, has the potential to be a molecular entry point into understanding the synaptic, developmental and circuit origins of the disorder.
 

5 Comments
February 2013
Opinion / Viewpoint

Risk factors

by ,  /  26 February 2013

To focus the search for environmental risk factors in autism, we should look for chemicals that influence the molecular pathways associated with candidate risk genes, say Pamela Lein and Marianna Stamou.

1 Comment
May 2012
News

Genetics: SHANK1 mutations found in men with autism

by  /  11 May 2012

Researchers have identified deletions in SHANK1 — the third member of a gene family that is closely linked to autism — in five men with the disorder, they reported 4 May in the American Journal of Human Genetics. This is the first study linking SHANK1 mutations to people with autism.

0 Comments
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