Mice with an extra copy of the autism risk gene UBE3A have cognitive deficits and anxiety, but do not show any core features of the condition.
Deleting one copy of a gene called MVP impairs the brain's ability to adapt to changes in the environment.
The effects of autism mutations on brain volume might be reversible, even in a mature brain.
Mice missing one copy of a top autism gene show many of the features seen in people with the mutation — but not social deficits.
Female mice with a large deletion linked to autism may compensate for its loss by upping the levels of a key protein.
More than 100 labs in 17 countries have built miniaturized microscopes that plug into the brains of mice.
Two mouse models of autism have distinct patterns of brain connectivity that emerge at different times.
By coaching mice to position themselves under a microscope, researchers can regularly peer into their brains without disrupting the rodents’ social life.
Subsets of neurons lacking a gene called RAI1 contribute to Smith-Magenis syndrome, a rare condition related to autism.
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