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Spectrum: Autism Research News

Tag: mouse models

May 2023
Research image of oligodendrocytes in mice treated with clemastine compared to untreated mice.

Antihistamine aids myelination in Pitt-Hopkins mice

by  /  25 May 2023

The drug clemastine and other compounds that fortify the protective sheath around neurons may prove therapeutic for some genetic neurodevelopmental conditions.

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Research image of developing mouse embryos.

Medley of models reveals misbehaving pathways in autism-linked condition

by  /  4 May 2023

The largest analysis of human samples to date, plus work in mice and zebrafish, detail the gene KMT5B’s role in brain development.

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April 2023
Research heatmap showing mice associating more with familiar mice than unfamiliar ones.

Loss of autism-linked gene dampens social interactions in animals

by  /  28 April 2023

Mice and zebrafish missing the GIGYF1 gene show social traits reminiscent of autism, though the molecular underpinnings are unclear.

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Image of allegedly duplicated data in a scientific paper.

Questions arise around two published studies from Harvard group

by  /  20 April 2023

An anonymous tipster has been sifting through the papers of Jia Liu and his team.

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Research image of cortical structures in mice.

Autism-linked mutations scramble nascent cortical circuits

by  /  17 April 2023

By imaging and recording synaptic activity in living mouse embryos for the first time, new research reveals previously unknown patterns of development and hints at how those patterns are disrupted in autism.

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Research image of the blood-brain barrier.

Rare autism-linked mutation starves growing neurons of essential nutrients

by  /  10 April 2023

The mutation prevents certain amino acids from entering neurons, causing the cells to die early in development.

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Six cross-sections of mouse brains.

Landmark atlases flag 5,000 cell types across mouse brain

by  /  6 April 2023

The work identifies new varieties and may help researchers develop tools to genetically target specific classes of cells.

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March 2023
Research image of cultured neurons.

Cannabis compound rebalances signaling to quell seizures in mice

by  /  22 March 2023

Cannabidiol (CBD) blocks the action of a molecule that drives an overexcitability feedback loop in a rodent model of epilepsy.

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Adapted research image of immunofluorescence staining of primary cortical neurons showing expression of PTBP proteins and reduced level of the protein SYNGAP1.

‘Splice-switching’ strategy boosts SYNGAP1 expression

by  /  21 March 2023

The approach improves the function of SYNGAP1-deficient neurons in vitro, but whether it will work in people remains unclear.

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Drop of liquid medicine with air bubbles is dripping from a pipette on a light pink background.

FDA approval of trofinetide may spur further drug development for Rett

by  /  16 March 2023

The drug, welcomed by patients, might be just the first of many.

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