Antihistamine aids myelination in Pitt-Hopkins mice
The drug clemastine and other compounds that fortify the protective sheath around neurons may prove therapeutic for some genetic neurodevelopmental conditions.
The drug clemastine and other compounds that fortify the protective sheath around neurons may prove therapeutic for some genetic neurodevelopmental conditions.
The largest analysis of human samples to date, plus work in mice and zebrafish, detail the gene KMT5B’s role in brain development.
Mice and zebrafish missing the GIGYF1 gene show social traits reminiscent of autism, though the molecular underpinnings are unclear.
An anonymous tipster has been sifting through the papers of Jia Liu and his team.
By imaging and recording synaptic activity in living mouse embryos for the first time, new research reveals previously unknown patterns of development and hints at how those patterns are disrupted in autism.
The mutation prevents certain amino acids from entering neurons, causing the cells to die early in development.
The work identifies new varieties and may help researchers develop tools to genetically target specific classes of cells.
Cannabidiol (CBD) blocks the action of a molecule that drives an overexcitability feedback loop in a rodent model of epilepsy.
The approach improves the function of SYNGAP1-deficient neurons in vitro, but whether it will work in people remains unclear.
The drug, welcomed by patients, might be just the first of many.