Tag: mouse models

November 2017
Week of NovemberNov
13th
2017
News / Spotted

Adult assessment; fragile therapy; neuron nirvana and more

by  /  17 November 2017

An interview for diagnosing adults on the spectrum clears its first hurdle, a fragile X drug eases multiple features of the syndrome in a mouse model, and a brain bank chronicles the beautiful diversity of neurons.

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Researchers advance models of maternal antibody link to autism

by  /  15 November 2017

Sophisticated animal models — including a new rat model — are revealing how maternal antibodies contribute to autism risk.

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Compound lets scientists see deep inside brains of living mice

by  /  15 November 2017

A chemical that doctors use to create contrast on X-rays also yields clear images of neurons in the brains of living mice.

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Selective enzyme block reveals new treatment for fragile X

by  /  14 November 2017

A drug that selectively blocks one form of an enzyme called GSK-3 prevents seizures and improves cognitive deficits in a mouse model of fragile X syndrome.

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News

Maternal asthma alters immune cells in fetal brain

by  /  14 November 2017

Mouse pups exposed to an immune response in the womb show autism-like behaviors and altered gene expression in brain cells called microglia.

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Chromosome 16 deletion miswires brain in people, mice

by  /  14 November 2017

Mice and people missing a copy of a chromosomal region called 16p11.2 show similar patterns of weak brain connections.

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Rett syndrome mutation’s effects vary by cell type

by  /  14 November 2017

Mutations in the Rett syndrome gene MECP2 have different effects on subtypes of neurons.

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Scientists move closer to gene therapy for Rett syndrome

by  /  14 November 2017

A virus that delivers a working copy of the Rett syndrome gene to the brain improves features of the condition in mice, and appears to be safe in monkeys.

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Rodent ratings reveal periods of vulnerability to harmful exposures

by  /  13 November 2017

Nongenetic rodent models most relevant to autism tend to be those exposed to environmental agents in the womb or shortly after birth.

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‘Fragile’ behaviors mar studies of popular autism mouse model

by  /  13 November 2017

Researchers should proceed with caution when studying the behavior of one of the most popular mouse models of autism: the fragile X mouse model.

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