Tag: hippocampus

March 2017
Illustration by Michela Buttignol

‘Triple-hit’ study may help explain autism’s male bias

by  /  20 March 2017

The absence of an autism-linked gene, combined with exposure to a mock infection, produces social deficits in mice — but only in males.

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Features / Deep Dive

Meet the newest contestant in the scientific rat race

by  /  15 March 2017

Mice have long been the mainstay of autism research, but a small group of scientists say rats are the superior choice. Rats are bigger, smarter, friendlier — and a lot more fun.

February 2017
Treat pursuit: Rats with a mutation in the SHANK2 gene press a lever for a reward about a hundred times more than controls before giving up.Dmitry Maslov / Getty Images

Rats with mutant SHANK genes show autism-like behaviors

by  /  16 February 2017

Researchers have engineered two new rats with mutations in a family of genes that function at neuronal junctions, they reported today at the 2014 International Meeting for Autism Research in Atlanta.

November 2016
Mouse brain hippocampus

New mice expose consequences of key autism gene

by  /  17 November 2016

Mice with an extra copy of the autism risk gene UBE3A have cognitive deficits and anxiety, but do not show any core features of the condition.

September 2016
In sync: 
 Neurons in the hippocampus of mice with too much (middle) or too little (bottom) MeCP2 fire more synchronously (black arrows) than do those in controls (top).

Loss, doubling of Rett gene produce similar brain glitch

by  /  15 September 2016

Mice with either too little or too much MeCP2, the gene mutated in Rett syndrome, show similar malfunctions in a learning and memory circuit.

August 2016
Audio only. The hippocampus is a brain region that looks like a seahorse. It helps form memories —  whether that’s the name of the fourth president of the United States or about yesterday’s trip to the mall. People with autism have little trouble holding onto facts, but they often have problems recalling visits to the mall and other life events. This gap may contribute to some of their social quirks.

Memory hub could underlie social, cognitive quirks of autism

by  /  24 August 2016

The brain’s memory center, the hippocampus, may provide clues to features of autism as disparate as personal relationships and decision-making.

Fast forward:  Gene expression patterns in the monkey visual cortex (red box) are similar to those in people during infancy (top brains), childhood (bottom left) and adulthood (bottom right).
News / Toolbox

Maps reveal genetic landscape of developing monkey brain

by  /  12 August 2016

Researchers have charted gene expression in the brains of rhesus macaques from before birth into adulthood.

May 2016
Social equals: Mice that carry a mutation in the autism gene CHD8 appear to be just as social as controls. 

© shutterstock.com / Emilia Stasiak

Mouse with key autism mutation defies expectations

by  /  14 May 2016

Mice with a mutation in CHD8, the top autism gene, show no signs of any of the condition’s core features.

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April 2016
Double trouble: A new imaging system allows researchers to read the activity of two different neuron types (green and purple) in the same brain region in mice.
News / Toolbox

Flexible tool watches brain talk as mice walk

by  /  27 April 2016

A new brain imaging system lets researchers eavesdrop on mouse neurons as the animals move around and interact with each other.

December 2015
Green light: Injecting a drug into the brain (right) lowers the expression of MeCP2 protein (green) in mice with an extra copy of the gene.

Drug eases symptoms of rare autism-like syndrome in mice

by  /  10 December 2015

A drug that curbs the expression of MeCP2, a gene duplicated in people with an autism-linked syndrome, normalizes brain function and reverses abnormal behaviors in mice.


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