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Spectrum: Autism Research News

Tag: GABA

September 2023
A hand reaches from above to add a pill to a stack that is resting against the x-axis of a graph.

Looking at eye tracking’s potential for clinical trials

by  /  28 September 2023

This month’s Going on Trial newsletter explores how eye tracking might be used beyond helping with diagnosis, among other drug development news.

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May 2023
Photograph of white pills and blister pack on blue pastel colored background.

Trials of arbaclofen for autism yield mixed results

by  /  5 May 2023

Autistic children taking the drug showed improvements in some behaviors but not in their social skills.

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March 2023
Research image of cultured neurons.

Cannabis compound rebalances signaling to quell seizures in mice

by  /  22 March 2023

Cannabidiol (CBD) blocks the action of a molecule that drives an overexcitability feedback loop in a rodent model of epilepsy.

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Still image showing activity of activity of neurons with genetic mutations in the 15q11-13 chromosomal region.

Single gene insufficient to account for dup15q, Angelman traits

by  /  21 March 2023

UBE3A, a key gene associated with both autism-linked conditions, can explain most — but not all — of the syndromes’ atypical neuronal properties.

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February 2023
Illustration of hybrid objects: part light bulb, part lab vial, some in blue and some in red to signify null and replicated results.

Null and Noteworthy: Busting biomarkers; going after GABA; reproducibility illusion

by  /  16 February 2023

In this edition of Null and Noteworthy, scientists find little to be excited about in research on biomarkers for neurodevelopmental conditions.

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January 2023
A hand reaches from above to add a pill to a stack that is resting against the x-axis of a graph.

Going on Trial: Arbaclofen reboot; cell implants; psilocybin microdoses

by  /  25 January 2023

Going on Trial rounds up new developments in autism-related drug trials. This month we’re revisiting decade-old data from a trial of arbaclofen for fragile X syndrome and looking into a new implant-based approach to quelling seizures, among other treatment strategies.

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November 2022
Single astrocyte on black background.

Mouse studies cast astrocytes as stars of sensory perception

by  /  13 November 2022

Data from two separate research teams suggest the cells are key to sensory hypersensitivity in fragile X syndrome.

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October 2022
Laura Cancedda in Iama's lab.

Building a better drug

by  /  6 October 2022

Iama Therapeutics is hoping a new class of molecule will prove successful against an old target in autism.

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July 2022
Illustration shows calcium signaling astrocytes, which are star-shaped and change color from light blue to purple.

Portrait of a research field: astrocytes in autism

by  /  14 July 2022

Long cast in supporting roles in the brain, astrocytes are now emerging as primary players in certain characteristics of autism and related conditions.

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New resource maps gene expression, regulation in neuron subtypes

by  /  1 July 2022

The catalog could help researchers understand the effects of autism-linked DNA variants that fall outside genes.

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