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Spectrum: Autism Research News

Tag: FMR1

November 2022
A white mouse sits on a nest against a blue background.

Mouse models help sniff out olfactory differences in autism

by  /  16 November 2022

A range of presentations at Neuroscience 2022 tie atypical social behavior to trouble discriminating between odors in the animals.

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Scan of a zebrafish brain showing neuron activity.

Decoding sensory brain networks: A quick take at SfN with Ethan Scott

by  /  15 November 2022

Scott describes his work on sound processing differences in the brains of zebrafish that model fragile X syndrome.

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Single astrocyte on black background.

Mouse studies cast astrocytes as stars of sensory perception

by  /  13 November 2022

Data from two separate research teams suggest the cells are key to sensory hypersensitivity in fragile X syndrome.

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September 2022
Brain slice of a mouse brain showing cells carrying the fragile X mutation.

Fragile X neurons develop atypically in chimeric mice

by  /  29 September 2022

After a brain transplant of reprogrammed human cells, the animals can for the first time recapitulate some neuronal changes seen in people with fragile X syndrome.

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Illustration of a binocular microscope with an X Chromosome in one eyepiece and cancer cells in the other.

The cloudy connection between fragile X and cancer

by  /  28 September 2022

People with the autism-linked syndrome lack a protein implicated in several cancers, but it’s unclear whether — or how — they are protected from malignancies.

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A brown lab mouse perches on a researcher's hand.

Largest-yet fragile X mutation in mice confirms model’s shortcomings

by  /  14 September 2022

A 341-repeat mutation from a person with fragile X does not lead to the syndrome’s traits or function the same way in mice, highlighting a need for different animal models.

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August 2022
Scientist Gül Dölen smiles while looking towards the window in her lab's office.

In deep water with Gül Dölen

by  /  3 August 2022

A researcher’s existential crisis led to a scientific breakthrough.

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July 2022

Plethora of protein-making machines in neurons may underlie fragile X

by  /  21 July 2022

An overabundance of ribosomes drives an imbalance of proteins produced from long and short genetic transcripts in a mouse model of fragile X syndrome.

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Illustration shows calcium signaling astrocytes, which are star-shaped and change color from light blue to purple.

Portrait of a research field: astrocytes in autism

by  /  14 July 2022

Long cast in supporting roles in the brain, astrocytes are now emerging as primary players in certain characteristics of autism and related conditions.

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May 2022
Ultrasound in black and white shows a pattern.

Heart anomalies abound in mouse models of autism

by  /  23 May 2022

Of nine genetic models examined in a new study, all had some incidence of cardiac abnormalities. But the problems varied widely depending on the affected genes.

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