Tag: dendritic spines

July 2017
News

Diabetes drug eases fragile X features in mice

by  /  3 July 2017

A drug used to treat type 2 diabetes reverses behavioral and brain abnormalities in a mouse model of fragile X syndrome.

1 Comment
June 2017
News

Maternal infection may alter neuronal signals, connections

by  /  9 June 2017

Pups born to pregnant mice infected with a mock virus are known to show changes in their immune system. These effects may in turn impair proper brain signaling, according to results presented Saturday at the 2013 Society for Neuroscience annual meeting in San Diego.

1 Comment
April 2017
News / Toolbox

Clever tweaks give brain scans new dimension

by  /  14 April 2017

New improvements allow researchers to look at cells deep inside the mouse brain, make high-resolution movies of firing neurons and monitor brain activity in monkeys over months.

0 Comments
November 2016
News

In autism, brain’s emotion hub begins with too many cells

by  /  13 November 2016

The amygdala, a brain region that governs emotions, may be enlarged and overly connected in children with autism, but it shrinks as the children grow up.

0 Comments
June 2015
News

Cell skeleton breakdown may spur autism symptoms in mice

by  /  15 June 2015

An autism-linked mutation in the SHANK3 gene alters the protein skeleton of mouse neurons. Repairing the scaffold eases the animals’ social deficits.

0 Comments
November 2014
Opinion

Exposure to ‘auntie’ mouse is therapeutic for fragile X mice

by  /  25 November 2014

A setup that mimics early behavioral intervention reverses social and cognitive deficits seen in a mouse model of fragile X syndrome.

3 Comments
News

Family of autism-linked proteins helps neurons communicate

by  /  16 November 2014

The SHANK family of proteins, some of which are strong autism candidates, work together to facilitate brain signaling, according to unpublished results presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.

0 Comments
September 2014
News

Brains of children with autism teem with surplus synapses

by  /  4 September 2014

The brains of children with autism do not prune unneeded connections between neurons as they age, leaving them with too many of these neuronal links, according to a study published 21 August in Neuron.

6 Comments
March 2014
News

Molecular mechanisms: Mild fragile X seen in partial mutants

by  /  4 March 2014

Removing the fragile X syndrome gene from two brain regions in mice leads to signaling defects but does not produce behavioral deficits, according to a study published in the February issue of Autism Research.

0 Comments
November 2013
Opinion / Viewpoint

SHANK mutations converge at neuronal junctions in autism

by ,  /  5 November 2013

SHANK3, one of the strongest candidate genes for autism, has the potential to be a molecular entry point into understanding the synaptic, developmental and circuit origins of the disorder.
 

5 Comments
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