A drug used to treat type 2 diabetes reverses behavioral and brain abnormalities in a mouse model of fragile X syndrome.
Pups born to pregnant mice infected with a mock virus are known to show changes in their immune system. These effects may in turn impair proper brain signaling, according to results presented Saturday at the 2013 Society for Neuroscience annual meeting in San Diego.
The amygdala, a brain region that governs emotions, may be enlarged and overly connected in children with autism, but it shrinks as the children grow up.
An autism-linked mutation in the SHANK3 gene alters the protein skeleton of mouse neurons. Repairing the scaffold eases the animals’ social deficits.
A setup that mimics early behavioral intervention reverses social and cognitive deficits seen in a mouse model of fragile X syndrome.
The SHANK family of proteins, some of which are strong autism candidates, work together to facilitate brain signaling, according to unpublished results presented yesterday at the 2014 Society for Neuroscience annual meeting in Washington, D.C.
The brains of children with autism do not prune unneeded connections between neurons as they age, leaving them with too many of these neuronal links, according to a study published 21 August in Neuron.
Removing the fragile X syndrome gene from two brain regions in mice leads to signaling defects but does not produce behavioral deficits, according to a study published in the February issue of Autism Research.
SHANK3, one of the strongest candidate genes for autism, has the potential to be a molecular entry point into understanding the synaptic, developmental and circuit origins of the disorder.
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