This year’s top papers deepen our understanding of autism’s genetics and reveal mixed results from trials of autism therapies.

People with mutations in CHD8, a top autism gene, tend to be tall and have large heads.

People who have mutations in a gene called PHF21A tend to have a constellation of traits and conditions, including autism.

A collection of rare genetic variants associated with autism and schizophrenia also seem to increase a person’s odds of having attention deficit hyperactivity disorder.

Mutations in the gene CSDE1 lead to a constellation of developmental delays and conditions, including autism, according to a new study.

Studying Smith-Magenis and Potocki-Lupski syndromes — two single-gene conditions in which people have trouble reading social cues — may boost our understanding of autism.

Neurons derived from autistic people with enlarged brains show extensive damage to long genes.

An analysis of whole-genome sequences from nearly 500 families has implicated 16 new genes in autism.

A new analysis challenges the idea that mutations in the sperm of older fathers lead to higher rates of autism among their children.

About 81 percent of autism risk comes from inherited genetic factors, according to an analysis of more than 2 million children from five countries.