Autism-linked mutation disrupts brain circuit to change social behavior
Therapies that target the circuit could boost social activity, new findings suggest.
Therapies that target the circuit could boost social activity, new findings suggest.
Model mice of the subtype also show hyperactivity in a signaling pathway called mTOR, bolstering the idea that distinct forms of autism have different biological roots and may require different treatment approaches.
Jolting a bundle of nerve fibers deep in the brain restores learning and memory in mice with mutations of the autism-linked gene CDKL5.
Four subtypes lend new support to the idea that there isn’t a single ‘hallmark’ type of brain connectivity in people with autism.
Activity patterns of neuronal networks link different genetic subtypes of autism that have similar traits, according to new unpublished research.
People who have large mutations associated with autism and schizophrenia share atypical patterns of brain connectivity, according to a new study, especially between areas that process sensory information.
Certain patterns of electrical activity in the brain may signal autism in children with tuberous sclerosis complex, a related genetic condition.
Mice that lack a segment of chromosome 22 — a mutation associated with autism — have unusually sparse connections between brain regions.
Autistic women show unusually strong connections, and autistic men unusually weak ones, between two brain regions.
A growing body of evidence suggests that autism involves atypical communication between brain regions, but how and where in the brain this plays out is unclear.