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Spectrum: Autism Research News

Tag: chromatin

October 2023
Research image of various types of cells.

Vast diversity of human brain cell types revealed in trove of new datasets

by  /  12 October 2023

The collection offers a glimpse into differences in cell composition — across people and brain regions — that may shape neural function.

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July 2023
Illustration of half of a brain on the left and half of a heart on the right

Change of heart and mind: Autism’s ties to cardiac defects

by  /  21 July 2023

Children with congenital heart disease have an increased likelihood of autism. Why?

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June 2023
Image of three developing axons.

Autism’s ties to the cell skeleton

by  /  22 June 2023

Many genes related to the condition play a role in the internal scaffolding of cells, and cytoskeletal disruptions can affect neurodevelopment and behavior.

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March 2023
A grid of brain scans.

To repair DNA, neurons harness autism-linked proteins

by  /  6 March 2023

The proteins are part of a newly discovered complex that mends genetic damage exclusively in neurons.

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February 2023
Illustration of neurons.

Chromatin remodeling tied to altered splicing in autism model

by  /  7 February 2023

Exposing neurons to valproic acid, a well-known environmental risk factor for autism, disrupts their ability to generate different proteins from the same gene.

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November 2022
Three-dimensional structure of cells in the cerebellum.

Flexible genomic architecture undergoes major redesigns during cerebellum development

by  /  13 November 2022

A new atlas reveals how the structural shake-ups within a cell’s genome differ by cell type and brain region over time.

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August 2022
Several strands of DNA with different openings at different points to show different functions for the same gene at different points in time

‘Double duty’ autism-linked genes upend conventional characterizations

by  /  23 August 2022

What these genes do and how they affect autism depends on when in development they’re studied, despite what classic ‘gene ontology’ analyses say.

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July 2022

New resource maps gene expression, regulation in neuron subtypes

by  /  1 July 2022

The catalog could help researchers understand the effects of autism-linked DNA variants that fall outside genes.

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April 2022

Histone-modifying drug improves autism-like behaviors in mice

by  /  18 April 2022

The experimental compound, called GSK-LSD1, enhances social preferences and reduces repetitive grooming in mice, according to a new study.

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February 2022

Three autism-linked genes converge on tweaks to cells’ timing

by  /  2 February 2022

Mutations in all three accelerate the maturation of inhibitory neurons, which could upset the brain’s balance of excitation and inhibition early in development.

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