News The latest developments in autism research.
Profiles Portraits of scientists who are making a mark on autism research.
Toolbox Emerging tools and techniques that may advance autism research.
Spotted A roundup of autism papers and media mentions you may have missed.
Opinion Conversations on the science of autism research.
Viewpoint Expert opinions on trends and controversies in autism research.
Columnists Dispatches from experts on various facets of autism.
Crosstalk Debates and conversations about timely topics in autism.
Reviews Exploring the intersection of autism and the arts.
Q&A Conversations with experts about noteworthy topics in autism.
Deep Dive In-depth analysis of important topics in autism.
Special Reports Curated collections of articles on special topics in autism.
Webinars Presentations by leading experts on their latest research.
News

Delayed pupil response to light may be early sign of autism

by  /  24 February 2017
Pupil progress: Pupil responses to light may change with age in typically developing children but not in children with autism.

Peter Kotoff / shutterstock
Editor's Note

This article was originally published 12 May 2016, based on preliminary data presented at the 2016 International Meeting for Autism Research in Baltimore. We have updated the article following publication of one of the studies 11 February 2017 in Autism Research1. Updates appear below in brackets.

The pupils of preschool-age children with autism are slow to constrict in response to light, according to results from two unpublished studies presented today at the 2016 International Meeting for Autism Research in Baltimore. The findings suggest that the pupillary reflex could serve as an early indicator of autism risk.

Researchers have seen a similarly lethargic response in children with autism older than 6 years. Both of the new studies extend this observation to younger affected children.

In one study, researchers asked [52] boys with autism and [52] typically developing boys, all between 2 and 6 years old, to watch a cartoon as an eye tracker measured the size and speed of their pupil reflexes. The cartoon was tinted red to minimize its effects on the pupil. Periodically, a bulb positioned above the screen flashed green light into the participants’ eyes.

The average pupil reflex in the autism group lagged about 10 milliseconds behind that of the control group, the researchers found. The two groups did not show any differences in overall pupil size at the start of the experiment or in the amount or speed of constriction in response to the light.

Age differences:

But important differences emerged with a child’s age. In typically developing children, pupil size and constriction speed increase with age, and the time it takes for the pupil to start constricting decreases with age. Children with autism, however, do not show these age-related patterns.

The delayed pupil reflex could be helpful for identifying children with autism at a young age, says Randima Dinalankara, a former graduate student in Gang Yao’s lab at the University of Missouri, Columbia who presented the findings.

[The altered pupil reflex may go along with impairments in other types of involuntary bodily functions. The participants’ parents completed a questionnaire about their child’s difficulties with physiological functions that, like the pupil reflex, the autonomic nervous system controls. These include sleep, heart rate, breathing, digestion and urination, as well as saliva and sweat production.

Children with autism in the study have significantly more trouble with these functions than typical children do. One of these functions appears to correlate with pupil size and degree of constriction: Typical children who sweat a lot have larger pupils and constrict their pupils less than those who sweat a typical amount. This correlation was not seen in children with autism, however, suggesting that children with autism may have altered regulation of multiple bodily functions.]

In the second study, 45 children with autism and 54 controls, all between 3 and 10 years old, watched a computer screen on which a large circle alternated from black to white as an eye tracker monitored their pupils.

The pupils of the children with autism constricted an average of 12 milliseconds later than those of controls when the circle changed to white. The researchers found no differences between the groups in the extent of pupil constriction or in the amount of time it takes for the pupil to fully constrict. Unlike the previous study, however, this study found no age-related differences in pupil size or constriction speed in children in either group.

This discrepancy in the findings might result from differences in the ages of the participants, or in differences in the light sources, says Veronica Kang, research study assistant in Wendy Stone’s lab at the University of Washington, Seattle who presented the work.

For more reports from the 2016 International Meeting for Autism Research, please click here.


References:
  1. Dinalankara D.M. et al. Autism Res. Epub ahead of print (2017) PubMed
  • Planet Autism

    Interesting. I am autistic and have multiple sensory issues including sensitivity to light and bright colours, both of which literally hurt my eyes. My chiropractor (of all people) tested my pupillary reflex and said it was slow. You’d think with my sensitivity to light and colours that my pupils would contract quickly. It’s a shame all these studies are done on children and so often, adults (most especially females) get left out of the loop. Surely if you want to understand what differs in autistics you would study the adults first, so you knew what to look for in the children.

  • Planet Autism

    This is one of those things, where I think they should investigate the genes in common with EDS and autism, as so many with autism have EDS as well, and perhaps the slow pupillary reflex is to do with the collagen defects (lax connective tissue possibly could account for slow contraction as many with autism and/or EDS have low muscle tone). There are genes in common, off the top of my head COMT might be one.

close

Log in to your Spectrum Wiki account

Email Address:

Password:


close

Request your Spectrum Wiki account

Spectrum Wiki is a community of researchers affiliated with an academic or research institutions. To be considered for participation, please fill out this form and a member of our team will respond to your request.

Name:

Email Address:

Title and Lab:

Area of Expertise:

Comments: