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Clinical research: Risperidone boosts milk hormone

by  /  29 March 2013

Side effect: Risperidone may alleviate repetitive behaviors in children with autism, but it leads to multiple side effects.

Long-term treatment with risperidone — an antipsychotic approved to treat autism — may boost levels of prolactin, a hormone that stimulates milk production, according to a study published in December in the Journal of Child and Adolescent Psychiatry1. Risperidone use may also affect sexual function and lead to enlarged breasts in males, the study found.

Risperidone is one of only two drugs approved by the U.S. Food and Drug Administration to treat symptoms of autism, specifically, hyperactivity and repetitive behavior. But it also has severe side effects, including weight gain, diabetes and heart abnormalities.

Another potential side effect, elevated prolactin, is of particular concern when treating children. Excess prolactin can dampen the production of estrogen and testosterone, which can have long-term consequences if it occurs during or around the time of puberty.

Though prolactin elevation is a known risk of short-term risperidone treatment, little is known about the effects of risperidone treatment over long periods
of time in children.

In the new study, researchers looked at the effect of long-term risperidone treatment on 10- to 20-year-old males who have autism or disrupted behavior disorder (a disorder characterized by tantrums and aggression). They compared 98 individuals who have one of these disorders, 51 of whom took risperidone for periods that ranged from 16 months to more than 10 years, and 47 of whom had never taken the drug.

Boys on risperidone are 72 times more likely to have elevated prolactin than those who don’t take the drug, the study found: 24 of 51 boys on risperidone and 1 of 47 controls have excess prolactin. Of those 24 boys who took risperidone, 5 have sexual side effects, including diminished sexual interest and erectile dysfunction, and 8 have enlarged breasts,
or gynecomastia.

The researchers also compared the effects of risperidone on these features, regardless of prolactin levels: 22 of 51 boys on risperidone and 10 of 47 controls have enlarged breasts, based on physical examination. And 7 boys who took risperidone and no controls have diminished sexual function, according to questionnaires.

There are caveats when using questionnaires to measure sexual function, as the participants may be too shy to be honest, the researchers say. Also, the survey asks for comparisons with the time prior to drug treatment. Children may not recall that time period accurately, or may have gone through puberty in the interim.

Clinicians should monitor young men on risperidone for diminished sexual function, which is the side effect most closely linked to risperidone treatment and elevated prolactin, the researchers say.


1: Roke Y. et al. J. Child Adolesc. Psychopharmacol. 22, 432-439 (2012) PubMed

  • Anonymous

    The clinical indication for risperidone in autism is for irritability associated with (not a symptom of) the disorder, not hyperactivity or repetitive behavior.

  • Anonymous

    Adolescents taking Risperidone on a long term basis seem to have diminished pleasure in eating,although seemingly still hungry. There appears to be no satisfaction mechanism in operation. Likewise this follows through in other areas of every day living.

  • Mary

    What is the latest regarding causing cognitive impairment in children. My son has been taking for 5 years since age 7. Is there any new research on this? or any anecdotal experience.

  • anon38

    risperidone risperdal etc.. one must be VERY cautious with this drug. it can really rearrange boys in an irreversible manner. it encourages the production of estrogen, a female hormone which can lead to permanent sterility, growth of female breasts in males, (basically castrates them). there are agents who take cases of those where doctors forced the med on their patients or convinced the parents to use it. the drug is very dangerous.

  • Anonymous

    My son’s doctor strongly encouraged this drug and told me that it was because he could provide samples and vouchers from drug rep. He diagnosed my son in 2002 with bi-polar disorder after one initial consultation and a family history. When I asked if he would be doing any other testing to confirm this diagnosis, he exclaimed that it was clear from the family history and that no further testing was needed. My son was 12 and took the drug for about 2 years. He is now 23, and his testosterone level is 254. His voice never changed, he has small breasts, and no energy. His doctor told me that the drug rep provided vouchers because the drug was expensive and that insurance was not yet covering it and that the drug company wanted to get this “miracle” drug to the people who need it. Turns out that the drug company wanted to start giving the drug to children so that they would have customers for life.


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