An unprecedented look at gene expression in tens of thousands of brain cells from autistic people suggests important roles in the condition for a neuronal subtype and for microglia.
Mice lacking one copy of a gene linked to autism are small and show striking changes in the number and quality of their cries.
A top autism gene called SCN2A plays a role at neuronal connections into adulthood, offering hope for treating mutations after infancy.
Rhesus macaques that are drawn to other monkeys’ faces in videos also tend to be highly social with their peers.
A new protocol enables researchers to rigorously test drugs for Angelman syndrome in mice.
Routine screening of toddlers for autism in China could lead to much earlier diagnosis of the condition.
The largest-ever set of sequences from people with developmental delay has revealed 43 new genetic diagnoses.
Clusters of brain cells — so-called ‘mini-brains’ grown in the lab — may help researchers understand how large stretches of duplicated or deleted DNA affect the brain.
Genes linked to autism in sequencing studies tend be located in long stretches of DNA that are duplicated or missing in some people with developmental conditions.
The largest autism sequencing study to date implicates 99 genes in the condition — but nearly half have a tighter link to intellectual disability or developmental delay.