Fragile X syndrome ...test all children presenting with developmental delay, intellectual disability or autism for fragile X syndrome, although only one to three percent of children tested are diagnosed with the syndrome. Relevance...
Epilepsy ...example fragile X syndrome and Rett syndrome. Consequently, the number of individuals with epilepsy who also have autism ranges widely, from 5 to 46 percent1. Though males are four times...
Neurotransmitters ...and inhibition is thought to contribute to the pathophysiology of autism spectrum disorders6,7. The FMRP protein, which is lacking in fragile X syndrome, regulates the metabotropic glutamate receptor 5 (mGLuR5)....
Dendritic spines ...signal-to-noise ratio of information transferred within neuronal circuits. Tissue from people with autism and fragile X syndrome seem to have unusually high spines densities, presumably due to a failure of...